Healthcare professionals | CONTRAVE® (naltrexone HCl/bupropion HCl) - WARNING: SUICIDAL THOUGHTS AND BEHAVIORS; AND NEUROPSYCHIATRIC REACTIONSSuicidality and Antidepressant DrugsCONTRAVE is not approved for use in the treatment of major depressive disorder or other psychiatric disorders. CONTRAVE contains bupropion, the same active ingredient as some other antidepressant medications (including, but not limited to, WELLBUTRIN, WELLBUTRIN SR, WELLBUTRIN XL, and APLENZIN). Antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term trials. These trials did not show an increase in the risk of suicidal thoughts and behavior with antidepressant use in subjects over age 24; there was a reduction in risk with antidepressant use in subjects aged 65 and older. In patients of all ages who are started on CONTRAVE, monitor closely for worsening, and for the emergence of suicidal thoughts and behaviors. Advise families and caregivers of the need for close observation and communication with the prescriber. CONTRAVE is not approved for use in pediatric patients.Neuropsychiatric Reactions in Patients Taking Bupropion for Smoking CessationSerious neuropsychiatric reactions have occurred in patients taking bupropion for smoking cessation. The majority of these reactions occurred during bupropion treatment, but some occurred in the context of discontinuing treatment. In many cases, a causal relationship to bupropion treatment is not certain, because depressed mood may be a symptom of nicotine withdrawal. However, some of the cases occurred in patients taking bupropion who continued to smoke. Although CONTRAVE is not approved for smoking cessation, observe all patients for neuropsychiatric reactions. Instruct the patient to contact a healthcare provider if such reactions occur.
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So I ordered two of these, one black for myself and one orange for my father. The orange one was much nicer than the black but both of them clearly have been cheaply mass produced. The coating on the retaining clips wears off very quickly BC the knives themselves appear to have been stamped out of a large sheet of metal and the edges left rough. On the black one there is even a small nick of medal on the unsharpened utility side, QC on these is poor to say the least. The inner edges of the bottle opener and oxygen tank wrench both have flakes of metal left behind that never got ground off. Also it is a shame the grips aren't made of something like g10 and better secured to the blade, the rubber they used feels like it will peel off. The design as a whole is great, though I feel the bottle opener is inappropriate considering the intended use of the knife, psa: don't mix drinking and extreme water sports. The sheath does work as advertised, and it is extremely snug on a belt. All in all I wish they had better quality control BC I have been eager to get this know ever since I first saw it years ago in the local outdoor sports shop, and I was really disappointed. I see better QC in 20$ knives on a regular basis, so when I invest in nicer knives for myself and my fam I have higher expectations.
Some nice changes to 2007, at least now all the programs share the same interface. Some changes are not for the business oriented user.
As I said, I use this for my beard. I had to discontinue use because work requires that I shave, so I figured there was no point to continue using it. Otherwise, it's great. It helps fill in patches on my beard and I believe even promotes body hair growth (which some consider a bad thing). Overall, I'd recommend it. As many others have had, it probably is best to consult with a doctor before doing it though.